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Nevertheless, pharmaceutical companies have pursued the twincretin concept, developing GLP-1/GIP dual agonists such as tirzepatide, an analogue biased in favour of GIP over GLP-1 activity [55], and NNC0090-2746, another analogue with balanced GLP-1 and GIP activity [56]

Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia

The future of GLP-1based medicines There are currently multiple once-weekly GLP-1RAs used to treat T2D, and two, liraglutide and semaglutide, are approved for therapy of people with obesity

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